Acquired Electronics360

Medical Devices and Healthcare IT

3-D Printed Porous Scaffold Promotes Bone Regeneration

27 February 2017

Torn or ruptured anterior cruciate ligaments (ACL) in the knee are a common injury for soccer, football, basketball and tennis players. According to Dr. Tarek O. Souryal, M.D., of the Texas Sports Medicine and Orthopaedic Group, between 250,000 and 300,000 ACL injuries occur per year, almost exclusively in athletes.

3-D printed bone scaffolding undergoes load to failure testing. / Photo courtesy of Tissue Engineering 3-D printed bone scaffolding undergoes load to failure testing. / Photo courtesy of Tissue Engineering However, by combining two cutting-edge technologies, researchers based out of the Mayo Clinic in Rochester, MN, have designed a way to improve bone regeneration, aiding in ACL reconstruction.

In an article published by Joshua Alan Parry, M.D., Sanjeev Kakar, M.D. and their co-authors in the peer-reviewed journal Tissue Engineering, the researchers detailed how 3-D printing and controlled release drug delivery work together to reconstruct stronger ACLs.

The researchers first demonstrated the strength of a 3-D-printed porous scaffold in a rabbit ACL construction model. Bone morphogenetic protein is traditionally delivered in collagen, according to the paper, resulting in an initial burst release with high tissue concentrations that decrease dramatically over time. However, by coating the scaffold in a carbonate hydroxyapatite mineral coating (synthetic bone material, or SBM) and polymer microspheres, the initial burst release of rhBMP-2 could be reduced, extending the release of the growth protein over time and resulting in better bone regeneration.

Future studies will compare the scaffold’s fixation strength and subsequent bone filling in vivo to determine if this is a suitable alternative to current therapies.

"This work is a good example of the fusion of technologies—controlled release drug delivery and 3-D printing," said Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, M.D., Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, in a press release issued by the journal.



Powered by CR4, the Engineering Community

Discussion – 0 comments

By posting a comment you confirm that you have read and accept our Posting Rules and Terms of Use.
Engineering Newsletter Signup
Get the Engineering360
Stay up to date on:
Features the top stories, latest news, charts, insights and more on the end-to-end electronics value chain.
Advertisement
Weekly Newsletter
Get news, research, and analysis
on the Electronics industry in your
inbox every week - for FREE
Sign up for our FREE eNewsletter
Advertisement

CALENDAR OF EVENTS

Date Event Location
30 Nov-01 Dec 2017 Helsinki, Finland
23-27 Apr 2018 Oklahoma City, Oklahoma
18-22 Jun 2018 Honolulu, Hawaii
Find Free Electronics Datasheets
Advertisement