Acquired Electronics360

Industrial Electronics

Electrically Charged Bandages Can Fight and Prevent Infections

06 November 2017

Researchers from The Ohio State University Wexner Medical Center have shown that special bandages using weak electric fields to disrupt bacterial biofilm infection can prevent infections, combat antibiotic resistance and enable healing on burn wounds for the first time. The bandage becomes electrically active when it comes into contact with bodily fluids.

Study shows electric bandages can fight biofilm infection, antimicrobial resistance. (The Ohio State University Wexner Medical Center)Study shows electric bandages can fight biofilm infection, antimicrobial resistance. (The Ohio State University Wexner Medical Center)

"Drug resistance in bacteria is a major threat, and antibiotic-resistant biofilm infections are estimated to account for at least 75 percent of bacterial infections in the United States," said Dr. Chandan Sen, director of Ohio State's Center for Regenerative Medicine & Cell-Based Therapies, who led the study with colleagues at the Medical Center's Comprehensive Wound Center and Center for Microbial Interface Technology. "This is the first pre-clinical long-term porcine study to recognize the potential of 'electroceuticals' as an effective platform technology to combat wound biofilm infection."

Bacterial biofilms represent a major wound complication. The resistance of biofilm towards drug interventions called for alternative strategies. Bacteria rely on electrostatic interaction to adhere to surfaces, an important aspect of biofilm formation. The concept that weak electric fields may have anti-biofilm property was first reported in 1992.

The study builds on Sen’s 2014 research with a wireless electroceutical dressing (WED) using silver and zinc printed on fabric. When moistened, WED generates a weak electric field without any external power supply and can be used like any other disposable dressing.

"The fact that wireless electric dressing is FDA-cleared and already in clinical use heightens the need to understand underlying mechanisms to enable optimal use," Sen said. "Since it relies on electrical principles, it's not subject to the mechanisms that may promote drug resistance. Understanding how this novel dressing may influence microbial, host and host-microbe interactions will determine the optimal use of this simple technology platform."

During the study, WED dressing was applied within two hours of wound infection in pigs to test its ability to prevent biofilm formation. In addition, WED was applied after seven days of infection to study disruption of established biofilm. Wounds were treated with placebo dressing or WED twice a week for 56 days. Both were proven successful.

During a burn injury, the barrier function of the skin is breached, leaving the body vulnerable. Patients with burn injuries risk dehydration, along with the potential of foreign agents like bacterial and allergen entering the body and cause potential health complications.

"Our study shows that WED may be viewed as a first generation electroceutical wound care dressing, and it also accelerated functional wound closure by restoring skin barrier function," Sen said. "Both from bacterial biofilm structure as well as host response perspectives, WED was consistently effective. No batteries or wires are needed because we harness the power of electrochemistry."

Ohio State researchers are teaming up with a burn care team within the Department of Defense to start a clinical trial within the next month to test this technology on burn wounds in humans.

A paper on this research was published in Annals of Surgery.

To contact the author of this article, email Siobhan.Treacy@ieeeglobalspec.com


Powered by CR4, the Engineering Community

Discussion – 0 comments

By posting a comment you confirm that you have read and accept our Posting Rules and Terms of Use.
Engineering Newsletter Signup
Get the Engineering360
Stay up to date on:
Features the top stories, latest news, charts, insights and more on the end-to-end electronics value chain.
Advertisement
Weekly Newsletter
Get news, research, and analysis
on the Electronics industry in your
inbox every week - for FREE
Sign up for our FREE eNewsletter
Advertisement

CALENDAR OF EVENTS

Date Event Location
30 Nov-01 Dec 2017 Helsinki, Finland
23-27 Apr 2018 Oklahoma City, Oklahoma
18-22 Jun 2018 Honolulu, Hawaii
Find Free Electronics Datasheets
Advertisement